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Article

Binding of a viral IRES to the 40S subunit occurs in two successive steps mediated by eS25.

Nucleic acids research - 20 Aug 2020

Walters Beth, Axhemi Armend, Jankowsky Eckhard, Thompson Sunnie R

Abstract excerpt

The mechanism for how internal ribosome entry sites (IRESs) recruit ribosomes to initiate translation of an mRNA is not completely understood. We investigated how a 40S subunit was recruited by the cricket paralysis virus intergenic region (CrPV IGR) IRES to form a stable 40S-IRES complex. Kinetic binding studies revealed that formation of the complex between the CrPV IGR and the 40S subunit consisted of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32609821
DOI: 10.1093/nar/gkaa547
PMCID: PMC7430650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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