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Hepatitis C Virus Translation Regulation

27 Mar 2020

Abstract excerpt

Translation of the hepatitis C virus (HCV) RNA genome is regulated by the internal ribosome entry site (IRES), located in the 5’-untranslated region (5′UTR) and part of the core protein coding sequence, and by the 3′UTR. The 5′UTR has some highly conserved structural regions, while others can assume different conformations. The IRES can bind to the ribosomal 40S subunit with high affinity without any other...

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PMID: 32230899
DOI: 10.3390/ijms21072328

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