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Article

Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution

8 Jul 2015

Abstract excerpt

Hepatitis C virus (HCV), a widespread human pathogen, is dependent on a highly structured 5'-untranslated region of its mRNA, referred to as internal ribosome entry site (IRES), for the translation of all of its proteins. The HCV IRES initiates translation by directly binding to the small ribosomal subunit (40S), circumventing the need for many eukaryotic translation initiation factors required for mRNA scanning....

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PMID: 26155016
DOI: 10.1038/ncomms8646

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