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Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and function

28 Oct 2014

Abstract excerpt

Translation initiation in the hepatitis C virus (HCV) occurs through a cap‐independent mechanism that involves an internal ribosome entry site (IRES) capable of interacting with and utilizing the eukaryotic translational machinery. In this review, we focus on the structural configuration of the different HCV IRES domains and the impact of IRES primary sequence variations on secondary structure conservation and...

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PMID: 25352252
DOI: 10.1002/wrna.1268

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