Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sites

10 Mar 2005

Abstract excerpt

Two exceptional mechanisms of eukaryotic translation initiation have recently been identified that differ fundamentally from the canonical factor-mediated, end-dependent mechanism of ribosomal attachment to mRNA. Instead, ribosomal 40S subunits bind in a factor-independent manner to the internal ribosomal entry site (IRES) in an mRNA. These two mechanisms are exemplified by initiation on the unrelated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15992743
DOI: 10.1016/j.crvi.2005.02.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sitesPMID 15992743Read ↗

Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodelingSemantic proximity Read ↗

Exploring Internal Ribosome Entry Sites as Therapeutic TargetsSemantic proximity Read ↗

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and functionSemantic proximity Read ↗

Hepatitis C Virus Translation RegulationSemantic proximity Read ↗

eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning.Semantic proximity Read ↗

Initiation of translation on nedicistrovirus and related intergenic region IRESs by their factor-independent binding to the P site of 80S ribosomesSemantic proximity Read ↗

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.Semantic proximity Read ↗

The hepatitis C virus internal ribosome-entry site: a new target for antiviral researchSemantic proximity Read ↗

Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunitSemantic proximity Read ↗

Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs.Semantic proximity Read ↗

Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo.Semantic proximity Read ↗

Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.