Article
The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function.
Nucleic acids research - 11 Mar 2015
Bhat Prasanna, Shwetha Shivaprasad, Sharma Divya Khandige, Joseph Agnel Praveen, Srinivasan Narayanaswamy, Das Saumitra
Abstract excerpt
Translation initiation in Hepatitis C Virus (HCV) is mediated by Internal Ribosome Entry Site (IRES), which is independent of cap-structure and uses a limited number of canonical initiation factors. During translation initiation IRES-40S complex formation depends on high affinity interaction of IRES with ribosomal proteins. Earlier, it has been shown that ribosomal protein S5 (RPS5) interacts with HCV IRES. Here,...
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