Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA

24 Nov 2004

Abstract excerpt

Protein synthesis in all cells begins with recruitment of the small ribosomal subunit to the initiation codon in a messenger RNA. In some eukaryotic viruses, RNA upstream of the coding region forms an internal ribosome entry site (IRES) that directly binds to the 40S ribosomal subunit and enables translation initiation in the absence of many canonical translation initiation factors. The hepatitis C virus (HCV)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA Research and Splicing
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15563596
DOI: 10.1073/pnas.0407402101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNAPMID 15563596Read ↗

Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodelingSemantic proximity Read ↗

Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolutionSemantic proximity Read ↗

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.Semantic proximity Read ↗

Structural Roles for Human Translation Factor eIF3 in Initiation of Protein SynthesisSemantic proximity Read ↗

Structure of the Hepatitis C Virus IRES Bound to the Human 80S Ribosome: Remodeling of the HCV IRESSemantic proximity Read ↗

Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation.Semantic proximity Read ↗

Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunitSemantic proximity Read ↗

HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assemblySemantic proximity Read ↗

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and functionSemantic proximity Read ↗

Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRESSemantic proximity Read ↗

Positioning of subdomain IIId and apical loop of domain II of the hepatitis C IRES on the human 40S ribosomeSemantic proximity Read ↗

Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.