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Article

LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex.

Nucleic acids research - 18 Feb 2016

Angulo Jenniffer, Ulryck Nathalie, Deforges Jules, Chamond Nathalie, Lopez-Lastra Marcelo, Masquida Benoît, Sargueil Bruno

Abstract excerpt

As obligatory intracellular parasites, viruses rely on cellular machines to complete their life cycle, and most importantly they recruit the host ribosomes to translate their mRNA. The Hepatitis C viral mRNA initiates translation by directly binding the 40S ribosomal subunit in such a way that the initiation codon is correctly positioned in the P site of the ribosome. Such a property is likely to be central for...

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Identifiers

PMID: 26626152
DOI: 10.1093/nar/gkv1325
PMCID: PMC4756818

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LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex.PMID 26626152Read ↗

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