Article
An AUG codon upstream of rev and env open reading frames ensures optimal translation of the simian immunodeficiency virus Env protein.
Virology - 5 Feb 2013
van der Velden Gisela J, Vink Monique A, Klaver Bep, Das Atze T, Berkhout Ben
Abstract excerpt
The mRNAs encoding the Rev and Env proteins of simian immunodeficiency virus (SIV) are unique because upstream translation start codons are present that may modulate the expression of these viral proteins. We previously reported the regulatory effect of a small upstream open reading frame (ORF) on Rev and Env translation. Here we study this mechanism in further detail by modulating the strength of the translation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.