Article
Potential control of human immunodeficiency virus type 1 asp expression by alternative splicing in the upstream untranslated region.
DNA and cell biology - 1 Jul 2012
Barbagallo Michael S, Birch Katherine E, Deacon Nicholas J, Mosse Jennifer A
Abstract excerpt
The negative-sense asp open reading frame (ORF) positioned opposite to the human immunodeficiency virus type 1 (HIV-1) env gene encodes the 189 amino acid, membrane-associated ASP protein. Negative-sense transcription, regulated by long terminal repeat sequences, has been observed early in HIV-1 infection in vitro. All subtypes of HIV-1 were scanned to detect the negative-sense asp ORF and to identify potential...
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