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Article

Effects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jul 2013

Choi Chang-Ik, Bae Jung-Woo, Keum Seul-Ki, Lee Yun-Jeong, Lee Hye-In, Jang Choon-Gon, Lee Seok-Yong

Abstract excerpt

1. The renal excretion of organic cation drugs, including lamivudine, is mostly mediated by OCT2 in vitro. To date, three putatively relevant single nucleotide polymorphisms (SNPs), including c.596C > T (p.Thr199Ile), c.602C > T (p.Thr201Met), and c.808G > T (p.Ala270Ser) have been observed in Asians. The effects of the SLC22A2 c.602C > T genetic variant on the pharmacokinetics of lamivudine were studied with...

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PMID: 23252721
DOI: 10.3109/00498254.2012.747710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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