Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro characterization of SLCO2B1 genetic variants.

Journal of pharmaceutical sciences - 1 Jun 2025

Sinokki Alli, Miinalainen Annika, Kivioja Saara, Kiander Wilma, Vellonen Kati-Sisko, Bhattacharya Madhushree, Gynther Mikko, Huttunen Kristiina M, Auriola Seppo, Niemi Mikko, Kidron Heidi

Abstract excerpt

OATP2B1, encoded by SLCO2B1, is a drug transporter expressed widely throughout the body in tissues such as the intestine and liver. Genetic variation of this transporter may lead to altered disposition of OATP2B1 substrate drugs, but especially the effects of rare variants are poorly understood. The aim of this study was to characterize the effects of naturally occurring missense single nucleotide variants of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Estrone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to HEK293 Cells

Share to Mutation, Missense

Share to Organic Anion Transporters

Share to Polymorphism, Single Nucleotide

Share to Rosuvastatin Calcium

Source

Identifiers

PMID: 40154787
DOI: 10.1016/j.xphs.2025.103772

Genes

SLCO2B1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro characterization of SLCO2B1 genetic variants.PMID 40154787Read ↗

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality.Semantic proximity Read ↗

Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1).Semantic proximity Read ↗

Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2.Semantic proximity Read ↗

Transmembrane Domain Single-Nucleotide Polymorphisms Impair Expression and Transport Activity of ABC Transporter ABCG2.Semantic proximity Read ↗

Functional characterization of six <i>SLCO1B1</i> (OATP1B1) variants observed in Finnish individuals with a psychotic disorderSemantic proximity Read ↗

Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C.Semantic proximity Read ↗

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1Semantic proximity Read ↗

Large-scale next generation sequencing based analysis of SLCO1B1 pharmacogenetics variants in the Saudi population.Semantic proximity Read ↗

In vitro identification of decreased function phenotype ABCG2 variants.Semantic proximity Read ↗

The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomicsSemantic proximity Read ↗

Pharmacogenetics of membrane transporters: a review of current approaches.Semantic proximity Read ↗

The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.