Article
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.
Pharmacogenetics - 1 Jul 2002
Leabman Maya K, Huang Conrad C, Kawamoto Michiko, Johns Susan J, Stryke Douglas, Ferrin Thomas E, DeYoung Joseph, Taylor Travis, Clark Andrew G, Herskowitz Ira, Giacomini Kathleen M
Abstract excerpt
The completion of the Human Genome Project and the development of high-throughput polymorphism identification methods have allowed researchers to carry out full genetic analyses of many clinically relevant genes. However, few studies have combined genetic analysis with in vitro phenotyping to better understand the relationship between genetic variation and protein function. Many transporters in the kidney are...
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