Article
Altered intrinsic brain functional connectivity in drug-naïve Parkinson's disease patients with LRRK2 mutations.
Neuroscience letters - 14 May 2018
Hou Yanbing, Luo Chunyan, Yang Jing, Ou Ruwei, Song Wei, Chen Yongping, Gong Qiyong, Shang Huifang
Abstract excerpt
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) has been recently identified as a causative gene of Parkinson's disease (PD), and the LRRK2 R1628P and G2385R mutations are common in ethnic Han-Chinese PD patients. However, the pathogenic mechanism of LRRK2 mutations in PD remains largely unknown. METHODS: Resting-state functional MRI (fMRI) was used to assess the functional connectivity (FC) of the striatal...
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