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Motor-planning cerebello-cerebral network alterations in PRRT2-related paroxysmal kinesigenic dyskinesia.

Parkinsonism & related disorders - 1 Mar 2026

Liao Weihao, Zhang Yingying, Ren Jiechuan, Huang Xiang, Lin Qiuxing, Huang Kailing, Li Yuming, Liu Peiwen, Cao Danyang, Li Wenhao, Li Xiuli, Yang Tianhua, Gong Qiyong, An Dongmei, Zhou Dong

Abstract excerpt

BACKGROUND AND OBJECTIVES: Emerging preclinical evidence suggests that the cerebellum plays a critical role in paroxysmal kinesigenic dyskinesia (PKD) associated with proline-rich transmembrane protein 2 (PRRT2) mutations. This study aimed to investigate the role of cerebello-cerebral network in PKD patients with PRRT2 mutations (PKD-M) and PKD patients with no PRRT2 mutations (PKD-N). METHODS: Resting-state...

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Identifiers

PMID: 41564648
DOI: 10.1016/j.parkreldis.2026.108195

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PRRT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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