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Article

Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele.

Brain : a journal of neurology - 1 Apr 2012

Anders Silke, Sack Benjamin, Pohl Anna, Münte Thomas, Pramstaller Peter, Klein Christine, Binkofski Ferdinand

Abstract excerpt

Patients with Parkinson's disease suffer from significant motor impairments and accompanying cognitive and affective dysfunction due to progressive disturbances of basal ganglia-cortical gating loops. Parkinson's disease has a long presymptomatic stage, which indicates a substantial capacity of the human brain to compensate for dopaminergic nerve degeneration before clinical manifestation of the disease....

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Identifiers

PMID: 22434215
DOI: 10.1093/brain/aws040
PMCID: PMC3326258

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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