Article
Genome-wide association study pinpoints a new functional apolipoprotein B variant influencing oxidized low-density lipoprotein levels but not cardiovascular events: AtheroRemo Consortium.
Circulation. Cardiovascular genetics - 1 Feb 2013
Mäkelä Kari-Matti, Seppälä Ilkka, Hernesniemi Jussi A, Lyytikäinen Leo-Pekka, Oksala Niku, Kleber Marcus E, Scharnagl Hubert, Grammer Tanja B, Baumert Jens, Thorand Barbara, Jula Antti, Hutri-Kähönen Nina, Juonala Markus, Laitinen Tomi, Laaksonen Reijo, Karhunen Pekka J, Nikus Kjell C, Nieminen Tuomo, Laurikka Jari, Kuukasjärvi Pekka, Tarkka Matti, Viik Jari, Klopp Norman, Illig Thomas, Kettunen Johannes, Ahotupa Markku, Viikari Jorma S A, Kähönen Mika, Raitakari Olli T, Karakas Mahir, Koenig Wolfgang, Boehm Bernhard O, Winkelmann Bernhard R, März Winfried, Lehtimäki Terho
Abstract excerpt
BACKGROUND: Oxidized low-density lipoprotein may be a key factor in the development of atherosclerosis. We performed a genome-wide association study on oxidized low-density lipoprotein and tested the impact of associated single-nucleotide polymorphisms (SNPs) on the risk factors of atherosclerosis and cardiovascular events. METHODS AND RESULTS: A discovery genome-wide association study was performed on a...
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