Article
Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events.
Atherosclerosis - 1 May 2014
Mäkelä Kari-Matti, Traylor Matthew, Oksala Niku, Kleber Marcus E, Seppälä Ilkka, Lyytikäinen Leo-Pekka, Hernesniemi Jussi A, Kähönen Mika, Bevan Steve, Rothwell Peter M, Sudlow Cathie, Dichgans Martin, Delgado Graciela, Grammer Tanja B, Scharnagl Hubert, Markus Hugh S, März Winfried, Lehtimäki Terho
Abstract excerpt
BACKGROUND AND PURPOSE: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). METHODS: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N = 2913 [271 cases]). We sought to replicate the results in a large genome-wide association...
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