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Overexpression of Escherichia coli nucleotide excision repair genes after cisplatin-induced damage.

DNA repair - 1 Jan 2013

Felício Deise Fonseca, Vidal Leonardo da Silva, Irineu Roberto Silva, Leitão Alvaro Costa, von Kruger Wanda Almeida, Britto Constança de Paoli, Cardoso Angélica, Cardoso Janine Simas, Lage Claudia

Abstract excerpt

Cisplatin is currently used in tumor chemotherapy to induce the death of malignant cells through blockage of DNA replication. It is a commonly used chemotherapeutic agent binding mono- or bifunctionally to guanines in DNA. Escherichia coli K12 mutant strains deficient in nucleotide excision repair (NER) were submitted to increasing concentrations of cisplatin, and the results revealed that uvrA and uvrB mutants...

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PMID: 23245695
DOI: 10.1016/j.dnarep.2012.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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