Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple pathways of recombination define cellular responses to cisplatin.

Chemistry & biology - 1 Jan 2000

Zdraveski Z Z, Mello J A, Marinus M G, Essigmann J M

Abstract excerpt

BACKGROUND: Cisplatin is a DNA-damaging drug used for treatment of testicular tumors. The toxicity of cisplatin probably results from its ability to form DNA adducts that inhibit polymerases. Blocked replication represents a particular challenge for tumor cells, which are committed to unremitting division. Recombination provides a mechanism by which replication can proceed despite the presence of lesions and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Cell Survival
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Linking Reagents

Share to DNA Damage

Share to DNA Repair

Share to Escherichia coli

Share to Recombination, Genetic

Source

Identifiers

PMID: 10662689
DOI: 10.1016/s1074-5521(00)00064-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple pathways of recombination define cellular responses to cisplatin.PMID 10662689Read ↗

The multifaceted functions of homologous recombination in dealing with replication-associated DNA damagesSemantic proximity Read ↗

Homologous recombination prevents methylation-induced toxicity in Escherichia coli.Semantic proximity Read ↗

Clinical relevance of the homologous recombination machinery in cancer therapySemantic proximity Read ↗

Overexpression of Escherichia coli nucleotide excision repair genes after cisplatin-induced damage.Semantic proximity Read ↗

Genetic analysis of repair and damage tolerance mechanisms for DNA-protein cross-links in Escherichia coli.Semantic proximity Read ↗

A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin TreatmentsSemantic proximity Read ↗

Homologous recombination and the roles of double-strand breaks.Semantic proximity Read ↗

Critical role of RecA and RecF proteins in strand break rejoining and maintenance of fidelity of rejoining following gamma-radiation-induced damage to pMTa4 DNA in E. coli.Semantic proximity Read ↗

Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.Semantic proximity Read ↗

DNA damage-processing pathways involved in the eukaryotic cellular response to anticancer DNA cross-linking drugs.Semantic proximity Read ↗

UvrD helicase suppresses recombination and DNA damage-induced deletions.Semantic proximity Read ↗

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.