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Cisplatin induces DNA double-strand break formation in Escherichia coli dam mutants.

DNA repair - 12 Jul 2005

Nowosielska Anetta, Marinus M G

Abstract excerpt

Escherichia coli dam cells are more susceptible to the cytotoxic action of cisplatin than wildtype. Dam mutS or dam mutL bacteria, however, are resistant to this agent indicating that active mismatch repair sensitizes dam cells to cisplatin toxicity. Genetic data, obtained previously, were consistent with the generation and repair of cisplatin-induced double-strand breaks (DSBs). We measured DSB formation in...

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PMID: 15925551
DOI: 10.1016/j.dnarep.2005.03.006

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