Participation of BER and NER pathways in the repair of DNA lesions induced at low N-nitrosodiethylamine concentrations.

doi:10.1016/j.toxlet.2004.07.012

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Article

Participation of BER and NER pathways in the repair of DNA lesions induced at low N-nitrosodiethylamine concentrations.

Toxicology letters - 1 Dec 2004

Aiub Claudia Alessandra Fortes, Mazzei José Luiz, Pinto Luis Felipe Ribeiro, Felzenszwalb Israel

Abstract excerpt

In the present work, we evaluated (p < 0.05) the participation of base excision repair (BER) and nucleotide excision repair (NER) mechanisms in repairing DNA lesions induced by N-nitrosodiethylamine (NDEA) at 1.5 ng/mL-36.5 microg/mL, through cell survival, in different single and double Escherichia coli DNA repair mutants (uvrA, uvrB, uvrC, fpg, nth, xthA, fpg/nth, uvrA/fpg, fpg/xthA, mutY, and fpg/mutY), using...

Topics

Alkylating Agents
Animals
Colony Count, Microbial
DNA Damage
DNA Repair
DNA, Bacterial
Diethylnitrosamine
Dose-Response Relationship, Drug
Escherichia coli
Microsomes, Liver
Mutation
Rats
Rats, Sprague-Dawley
SOS Response, Genetics

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Open in PubMed

Identifiers

PMID: 15475187
DOI: 10.1016/j.toxlet.2004.07.012

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