Article
Genetic analysis of repair and damage tolerance mechanisms for DNA-protein cross-links in Escherichia coli.
Journal of bacteriology - 1 Sept 2009
Salem Amir M H, Nakano Toshiaki, Takuwa Minako, Matoba Nagisa, Tsuboi Tomohiro, Terato Hiroaki, Yamamoto Kazuo, Yamada Masami, Nohmi Takehiko, Ide Hiroshi
Abstract excerpt
DNA-protein cross-links (DPCs) are unique among DNA lesions in their unusually bulky nature. We have recently shown that nucleotide excision repair (NER) and RecBCD-dependent homologous recombination (HR) collaboratively alleviate the lethal effect of DPCs in Escherichia coli. In this study, to gain further insight into the damage-processing mechanism for DPCs, we assessed the sensitivities of a panel of...
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