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Article

Evidence for multi‐site closure of the neural tube in humans

1 Oct 1993

Abstract excerpt

Abstract Four separate initiation sites for neural tube (NT) fusion have been demonstrated recently in mice and other experimental animals. We evaluated the question of whether the mult‐site model vs. the traditional single‐site model of NT closure provided the best explanation for neural tube defects (NTDs) in humans. Evidence for segmental vs. continuous NT closure was obtained by review of our recent clinical...

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Identifiers

PMID: 8267004
DOI: 10.1002/ajmg.1320470528

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