Pathobiology and genetics of neural tube defects.

doi:10.1046/j.1528-1157.44.s3.5.x

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Article

Pathobiology and genetics of neural tube defects.

Epilepsia - 1 Jan 2003

Finnell Richard H, Gould Amy, Spiegelstein Ofer

Abstract excerpt

PURPOSE: Neural tube defects (NTDs), including spina bifida and anencephaly, are common congenital malformations that occur when the neural tube fails to achieve proper closure during early embryogenesis. Based on epidemiological and clinical data obtained over the last few decades, it is apparent that these multifactorial defects have a significant genetic component to their etiology that interacts with specific...

Topics

Animals
Anticonvulsants
Carbamazepine
Epilepsy
Female
Folic Acid
Genetic Predisposition to Disease
Humans
Infant, Newborn
Mice
Mice, Neurologic Mutants
Neural Tube Defects
Pharmacogenetics
Pregnancy
Pregnancy Complications
Risk Factors
Spinal Dysraphism

Source

Open in PubMed

Identifiers

PMID: 12790882
DOI: 10.1046/j.1528-1157.44.s3.5.x

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