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Article

Biomechanical coupling facilitates spinal neural tube closure in mouse embryos

12 Jun 2017

Abstract excerpt

Significance Neurulation has been intensively studied in lower vertebrates, but marked species differences call into question the relevance of these models for human neural tube (NT) closure. Here, using mouse embryos, we demonstrate that mammalian neural fold apposition results from constriction of the open posterior NT, which is biomechanically coupled to the zippering point by an F-actin network. Using the...

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PMID: 28607062
DOI: 10.1073/pnas.1700934114

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