Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.

doi:10.1038/ng.2483

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Article

Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.

Nature genetics - 1 Jan 2013

Jiang De-Ke, Sun Jielin, Cao Guangwen, Liu Yao, Lin Dongxin, Gao Yu-Zhen, Ren Wei-Hua, Long Xi-Dai, Zhang Hongxing, Ma Xiao-Pin, Wang Zhong, Jiang Wei, Chen Tao-Yang, Gao Yong, Sun Liang-Dan, Long Ji-Rong, Huang Hui-Xing, Wang Dan, Yu Hongjie, Zhang Pengyin, Tang Li-Sha, Peng Bo, Cai Hao, Liu Ting-Ting, Zhou Ping, Liu Fang, Lin Xiaoling, Tao Sha, Wan Bo, Sai-Yin He-Xi Ge, Qin Lun-Xiu, Yin Jianhua, Liu Li, Wu Chen, Pei Yan, Zhou Yuan-Feng, Zhai Yun, Lu Pei-Xin, Tan Aihua, Zuo Xian-Bo, Fan Jia, Chang Jiang, Gu Xiaoli, Wang Neng-Jin, Li Yang, Liu Yin-Kun, Zhai Kan, Zhang Hongwei, Hu Zhibin, Liu Jun, Yi Qing, Xiang Yongbing, Shi Rong, Ding Qiang, Zheng Wei, Shu Xiao-Ou, Mo Zengnan, Shugart Yin Yao, Zhang Xue-Jun, Zhou Gangqiao, Shen Hongbing, Zheng S Lilly, Xu Jianfeng, Yu Long

Abstract excerpt

To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases and 1,353 controls) followed by a 2-stage validation among 6 independent populations of chronic HBV carriers (4,319 cases and 4,966 controls). The joint analyses showed that HCC...

Topics

Carcinoma, Hepatocellular
Gene Expression
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ Antigens

Hepatitis B

Hepatitis B virus

Humans

Liver Neoplasms

Polymorphism, Single Nucleotide

STAT4 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 23242368
DOI: 10.1038/ng.2483
PMCID: PMC4105840

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23242368-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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