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Article

A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2013

Clark Adam, Gerlach Franziska, Tong Hoang van, Hoan Nghiem Xuan, Song Le H, Toan Nguyen L, Bock C-Thomas, Kremsner Peter G, Velavan Thirumalaisamy P

Abstract excerpt

Two polymorphisms in the STAT4 and HLA-DQ loci were more recently reported to associate with chronic hepatitis B (CHB) induced hepatocellular carcinoma (HCC). We utilised an independent Vietnamese cohort of clinically classified HBV patients of chronic hepatitis B carriers (n=206), liver cirrhosis (n=222) and hepatocellular carcinoma (n=239) and assessed the influence of the reported variants. The STAT4 variant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23748017
DOI: 10.1016/j.meegid.2013.05.025

Genes

STAT4
AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma.PMID 23748017Read ↗

Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.Semantic proximity Read ↗

STAT4 gene polymorphism and risk of chronic hepatitis B-induced hepatocellular carcinoma.Semantic proximity Read ↗

Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in STAT3 and STAT4 and Risk of Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B.Semantic proximity Read ↗

Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci of STAT4 and HLA-DQ in a Korean population.Semantic proximity Read ↗

A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B.Semantic proximity Read ↗

Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.Semantic proximity Read ↗

Association of Single Nucleotide Polymorphism rs1053004 in Signal Transducer and Activator of Transcription 3 (STAT3) with Susceptibility to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B.Semantic proximity Read ↗

The effects of the interactions of STAT4 rs7574865 with HBV mutations on the risk of hepatocellular carcinoma.Semantic proximity Read ↗

Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B.Semantic proximity Read ↗

STAT4 genetic polymorphisms association with spontaneous clearance of hepatitis B virus infection.Semantic proximity Read ↗

Evaluation of STAT3 rs1053004 single nucleotide polymorphism in patients with chronic hepatitis B and hepatocellular carcinoma.Semantic proximity Read ↗

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