Article
A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B.
Alimentary pharmacology & therapeutics - 1 Sept 2018
El Sharkawy R, Thabet K, Lampertico P, Petta S, Mangia A, Berg T, Metwally M, Bayoumi A, Boonstra A, Brouwer W P, Smedile A, Abate M L, Loglio A, Douglas M W, Khan A, Santoro R, Fischer J, Leeming D J, Liddle C, George J, Eslam M
Abstract excerpt
BACKGROUND: Host genetic modifiers of the natural history of chronic hepatitis B (CHB) remain poorly understood. Recently, a genome-wide association study (GWAS)-identified polymorphism in the STAT4 gene that contributes to the risk for hepatocellular carcinoma (HCC) was shown to be associated with the full spectrum of hepatitis B virus (HBV) outcomes in Asian patients. However, the functional mechanisms for this...
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