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Article

Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.

American journal of physiology. Heart and circulatory physiology - 15 Feb 2013

Hecker Peter A, Leopold Jane A, Gupte Sachin A, Recchia Fabio A, Stanley William C

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the pentose phosphate pathway and produces NADPH to fuel glutathione recycling. G6PD deficiency is the most common enzyme deficiency in humans and affects over 400 million people worldwide; however, its impact on cardiovascular disease is poorly understood. The glutathione pathway is paramount to antioxidant defense, and...

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Identifiers

PMID: 23241320
DOI: 10.1152/ajpheart.00721.2012
PMCID: PMC3566485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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