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Article

Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.

Toxicological sciences : an official journal of the Society of Toxicology - 1 May 2016

Sun Wanqing, Quan Nanhu, Wang Lin, Yang Hui, Chu Dongyang, Liu Quan, Zhao Xuezhong, Leng Jiyan, Li Ji

Abstract excerpt

Pyruvate dehydrogenase (PDH) plays a key role in aerobic energy metabolism and occupies a central crossroad between glycolysis and the tricarboxylic acid cycle. We generated inducible cardiac-specific PDH E1α knockout (CreER(T2)-PDH(flox/flox)) mice that demonstrated a high mortality rate. It was hypothesized that PDH modulating cardiac glucose metabolism is crucial for heart functions under normal physiological...

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Identifiers

PMID: 26884059
DOI: 10.1093/toxsci/kfw035
PMCID: PMC4914805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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