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Article

Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase.

Circulation - 24 Feb 2004

Jain Mohit, Cui Lei, Brenner Daniel A, Wang Bo, Handy Diane E, Leopold Jane A, Loscalzo Joseph, Apstein Carl S, Liao Ronglih

Abstract excerpt

BACKGROUND: Free radical injury contributes to cardiac dysfunction during ischemia-reperfusion. Detoxification of free radicals requires maintenance of reduced glutathione (GSH) by NADPH. The principal mechanism responsible for generating NADPH and maintaining GSH during periods of myocardial ischemia-reperfusion remains unknown. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose...

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Identifiers

PMID: 14757696
DOI: 10.1161/01.CIR.0000112605.43318.CA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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