Article
Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice.
JCI insight - 22 Jul 2021
D'Alessandro Angelo, Howie Heather L, Hay Ariel M, Dziewulska Karolina H, Brown Benjamin C, Wither Matthew J, Karafin Matthew, Stone Elizabeth F, Spitalnik Steven L, Hod Eldad A, Francis Richard O, Fu Xiaoyun, Thomas Tiffany, Zimring James C
Abstract excerpt
Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is the single most common enzymopathy, present in approximately 400 million humans (approximately 5%). Its prevalence is hypothesized to be due to conferring resistance to malaria. However, G6PD deficiency also results in hemolytic sequelae from oxidant stress. Moreover, G6PD deficiency is associated with kidney disease, diabetes, pulmonary hypertension,...
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