Article
Analysis of HIV using a high resolution melting (HRM) diversity assay: automation of HRM data analysis enhances the utility of the assay for analysis of HIV incidence.
PloS one - 1 Jan 2012
Cousins Matthew M, Swan David, Magaret Craig A, Hoover Donald R, Eshleman Susan H
Abstract excerpt
BACKGROUND: HIV diversity may be a useful biomarker for discriminating between recent and non-recent HIV infection. The high resolution melting (HRM) diversity assay was developed to quantify HIV diversity in viral populations without sequencing. In this assay, HIV diversity is expressed as a single numeric HRM score that represents the width of a melting peak. HRM scores are highly associated with diversity...
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