Article
HIV diversity as a biomarker for HIV incidence estimation: including a high-resolution melting diversity assay in a multiassay algorithm.
Journal of clinical microbiology - 1 Jan 2014
Cousins Matthew M, Konikoff Jacob, Laeyendecker Oliver, Celum Connie, Buchbinder Susan P, Seage George R, Kirk Gregory D, Moore Richard D, Mehta Shruti H, Margolick Joseph B, Brown Joelle, Mayer Kenneth H, Koblin Beryl A, Wheeler Darrell, Justman Jessica E, Hodder Sally L, Quinn Thomas C, Brookmeyer Ron, Eshleman Susan H
Abstract excerpt
Multiassay algorithms (MAAs) can be used to estimate cross-sectional HIV incidence. We previously identified a robust MAA that includes the BED capture enzyme immunoassay (BED-CEIA), the Bio-Rad Avidity assay, viral load, and CD4 cell count. In this report, we evaluated MAAs that include a high-resolution melting (HRM) diversity assay that does not require sequencing. HRM scores were determined for eight regions...
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