Article
A comparison of two measures of HIV diversity in multi-assay algorithms for HIV incidence estimation.
PloS one - 1 Jan 2014
Cousins Matthew M, Konikoff Jacob, Sabin Devin, Khaki Leila, Longosz Andrew F, Laeyendecker Oliver, Celum Connie, Buchbinder Susan P, Seage George R, Kirk Gregory D, Moore Richard D, Mehta Shruti H, Margolick Joseph B, Brown Joelle, Mayer Kenneth H, Kobin Beryl A, Wheeler Darrell, Justman Jessica E, Hodder Sally L, Quinn Thomas C, Brookmeyer Ron, Eshleman Susan H
Abstract excerpt
BACKGROUND: Multi-assay algorithms (MAAs) can be used to estimate HIV incidence in cross-sectional surveys. We compared the performance of two MAAs that use HIV diversity as one of four biomarkers for analysis of HIV incidence. METHODS: Both MAAs included two serologic assays (LAg-Avidity assay and BioRad-Avidity assay), HIV viral load, and an HIV diversity assay. HIV diversity was quantified using either a high...
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