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Article

Analysis of HIV diversity using a high-resolution melting assay.

AIDS research and human retroviruses - 1 Aug 2010

Towler William I, James Maria M, Ray Stuart C, Wang Lei, Donnell Deborah, Mwatha Anthony, Guay Laura, Nakabiito Clemensia, Musoke Philippa, Jackson J Brooks, Eshleman Susan H

Abstract excerpt

HIV viruses are usually genetically homogeneous shortly after infection, and become more heterogeneous over time. We developed a high-resolution melting (HRM) assay to analyze HIV diversity without sequencing. Plasma samples from the HIVNET 012 trial were obtained from nine Ugandan mother-infant pairs. DNA amplified from the HIV gag region was analyzed to determine the number of degrees over which the DNA melted...

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Identifiers

PMID: 20666583
DOI: 10.1089/aid.2009.0259
PMCID: PMC2920076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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