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Article

Comparison of a high-resolution melting assay to next-generation sequencing for analysis of HIV diversity.

Journal of clinical microbiology - 1 Sept 2012

Cousins Matthew M, Ou San-San, Wawer Maria J, Munshaw Supriya, Swan David, Magaret Craig A, Mullis Caroline E, Serwadda David, Porcella Stephen F, Gray Ronald H, Quinn Thomas C, Donnell Deborah, Eshleman Susan H, Redd Andrew D

Abstract excerpt

Next-generation sequencing (NGS) has recently been used for analysis of HIV diversity, but this method is labor-intensive, costly, and requires complex protocols for data analysis. We compared diversity measures obtained using NGS data to those obtained using a diversity assay based on high-resolution melting (HRM) of DNA duplexes. The HRM diversity assay provides a single numeric score that reflects the level of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22785188
DOI: 10.1128/JCM.01460-12
PMCID: PMC3421787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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