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Article

Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2016

Fokina Valentina M, Xu Meixiang, Rytting Erik, Abdel-Rahman Sherif Z, West Holly, Oncken Cheryl, Clark Shannon M, Ahmed Mahmoud S, Hankins Gary D V, Nanovskaya Tatiana N

Abstract excerpt

Bupropion sustained release is used to promote smoking cessation in males and nonpregnant females. However, its efficacy as a smoking cessation aid during pregnancy is not reported. The pregnancy-associated changes in maternal physiology may alter the pharmacokinetics and pharmacodynamics of bupropion and consequently its efficacy in pregnant smokers. Therefore, the aims of this study were to determine the...

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Identifiers

PMID: 27528039
DOI: 10.1124/dmd.116.071530
PMCID: PMC5074472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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