Article
Pharmacogenetic investigation of smoking cessation treatment.
Pharmacogenetics - 1 Nov 2002
Lerman Caryn, Shields Peter G, Wileyto E Paul, Audrain Janet, Pinto Angela, Hawk Larry, Krishnan Shiva, Niaura Ray, Epstein Leonard
Abstract excerpt
Despite the efficacy of bupropion for smoking cessation, smokers exhibit variability in treatment outcome. The CYP2B6 gene has been implicated in bupropion kinetics and nicotine metabolism, and is a plausible candidate for pharmacogenetic studies of treatment response. We investigated whether a functional genetic polymorphism in the CYP2B6 gene predicts smoking outcomes in a placebo-controlled randomized trial....
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