Article
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease.
Acta neuropathologica - 1 Feb 2013
Pera Marta, Alcolea Daniel, Sánchez-Valle Raquel, Guardia-Laguarta Cristina, Colom-Cadena Martí, Badiola Nahuai, Suárez-Calvet Marc, Lladó Albert, Barrera-Ocampo Alvaro A, Sepulveda-Falla Diego, Blesa Rafael, Molinuevo José L, Clarimón Jordi, Ferrer Isidre, Gelpi Ellen, Lleó Alberto
Abstract excerpt
Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes. Studies from families with ADAD have been critical to support the amyloid cascade hypothesis of Alzheimer disease (AD), the basis for the current development of amyloid-based disease-modifying therapies in sporadic AD (SAD). However, whether the pathological changes...
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