Article
Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.
Human mutation - 1 Jul 2006
Kumar-Singh Samir, Theuns Jessie, Van Broeck Bianca, Pirici Daniel, Vennekens Krist'l, Corsmit Ellen, Cruts Marc, Dermaut Bart, Wang Rong, Van Broeckhoven Christine
Abstract excerpt
The varied ways in which mutations in presenilins (PSEN1 and PSEN2) affect amyloid b precursor protein (APP) processing in causing early-onset familial Alzheimer disease (FAD) are complex and not yet properly understood. Nonetheless, one useful diagnostic marker is an increased ratio of Ab42 to Ab40 (Ab42/Ab40) in patients' brain and biological fluids as well as in transgenic mice and cells. We studied Ab and APP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.