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Article

Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease.

Molecular neurobiology - 1 Jan 2000

Huse J T, Doms R W

Abstract excerpt

Accumulation of the amyloid-beta (A beta) peptide in the central nervous system (CNS) is considered by many to be the crucial pathological insult that ultimately leads to the development of Alzheimer's disease (AD). Regulating the production and/or aggregation of A beta could therefore be of considerable benefit to patients afflicted with AD. It has long been known that A beta is derived from the proteolytic...

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Identifiers

PMID: 11414282
DOI: 10.1385/MN:22:1-3:081

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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