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Article

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.

Current Alzheimer research - 1 Jan 2015

Baranello Robert J, Bharani Krishna L, Padmaraju Vasudevaraju, Chopra Nipun, Lahiri Debomoy K, Greig Nigel H, Pappolla Miguel A, Sambamurti Kumar

Abstract excerpt

Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP) and cerebrovascular amyloid protein deposits that are defining diagnostic features of Alzheimer's disease (AD). A number of rare mutations linked to familial AD (FAD) on the Aβ precursor protein (APP), Presenilin-1 (PS1), Presenilin- 2 (PS2), Adamalysin10, and other genetic risk factors for sporadic AD such as the ε4 allele of...

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Source

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Identifiers

PMID: 25523424
DOI: 10.2174/1567205012666141218140953
PMCID: PMC4820400

Genes

APP
ACE
BACE1
IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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