Article
Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease.
Neurochemistry international - 1 Sept 2009
Hellström-Lindahl E, Viitanen M, Marutle A
Abstract excerpt
Mutations in presenilin (PS) and amyloid precursor protein (APP) genes are a predominant cause for early-onset familial Alzheimer disease (AD). Although these mutations are rare, they have in the past decades advanced our understanding of the underlying molecular mechanisms of AD. In the present study, Abeta levels were measured in cortical regions of APPsw and PS1 (M146V) mutation carriers, sporadic AD (SAD) and...
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