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Article

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models.

Acta neuropathologica communications - 8 Mar 2016

Reinert Jochim, Richard Bernhard C, Klafki Hans W, Friedrich Beate, Bayer Thomas A, Wiltfang Jens, Kovacs Gabor G, Ingelsson Martin, Lannfelt Lars, Paetau Anders, Bergquist Jonas, Wirths Oliver

Abstract excerpt

In Alzheimer's disease (AD) a variety of amyloid β-peptides (Aβ) are deposited in the form of extracellular diffuse and neuritic plaques (NP), as well as within the vasculature. The generation of Aβ from its precursor, the amyloid precursor protein (APP), is a highly complex procedure that involves subsequent proteolysis of APP by β- and γ-secretases. Brain accumulation of Aβ due to impaired Aβ degradation and/or...

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Source

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Identifiers

PMID: 26955942
DOI: 10.1186/s40478-016-0294-7
PMCID: PMC4784385

Genes

APP
PSEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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