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Article

Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients.

Experimental neurology - 1 Sept 2003

Olsson Annika, Höglund Kina, Sjögren Magnus, Andreasen Niels, Minthon Lennart, Lannfelt Lars, Buerger Katharina, Möller Hans Jürgen, Hampel Harald, Davidsson Pia, Blennow Kaj

Abstract excerpt

One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) and Abeta. We examined the cerebrospinal fluid (CSF) for alpha- and beta-secretase cleaved sAPP...

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PMID: 12957490
DOI: 10.1016/s0014-4886(03)00027-x

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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