Article

Plasma Aβ ratios in autosomal dominant Alzheimer’s disease: the influence of genotype

2021-02-12

Abstract excerpt

In-vitro studies of autosomal dominant Alzheimer’s disease (ADAD) implicate longer Aβ peptides in pathogenesis, however less is known about the behaviour of ADAD mutations in-vivo . In this cross-sectional cohort study, we used liquid chromatography-tandem mass spectrometry to analyse 66 plasma samples from ADAD family members who were at-risk of inheriting a mutation or were already symptomatic. We tested for di...

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Literature Corpus work: 367bca26-a8f1-52fd-9c39-08637c9160a9
DOI: 10.1101/2021.02.11.430756

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