Neprilysin-sensitive amyloidogenic Aβ versus IDE-sensitive soluble Aβ: a probable mechanistic cause for sporadic Alzheimer’s disease

Abstract excerpt

Neprilysin (NEP) and insulin-degrading enzyme (IDE) are considered the two major catabolic enzymes that degrade amyloid β peptide (Aβ), the primary cause of Alzheimer’s disease (AD). However, their roles in Aβ metabolism in vivo have never been compared in an impartial and side-by-side manner. Here, we crossbred single App knock-in mice with NEP ( Mme ) KO mice and with IDE ( Ide ) KO mice to generate double m...

Topics

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• Alzheimer Disease
• Amyloid beta-Peptides
• Amyloid beta-Protein Precursor
• Insulysin
• Mice, Knockout
• Mice, Transgenic
• Neprilysin
• Plaque, Amyloid

Identifiers and source

Literature Corpus work

4aaadb40-b6af-5931-877a-f965280a96db

DOI

10.1101/2021.08.22.457281