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Article

The structural basis of direct glucocorticoid-mediated transrepression.

Nature structural & molecular biology - 1 Jan 2013

Hudson William H, Youn Christine, Ortlund Eric A

Abstract excerpt

A newly discovered negative glucocorticoid response element (nGRE) mediates DNA-dependent transrepression by the glucocorticoid receptor (GR) across the genome and has a major role in immunosuppressive therapy. The nGRE differs dramatically from activating response elements, and the mechanism driving GR binding and transrepression is unknown. To unravel the mechanism of nGRE-mediated transrepression by the GR, we...

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Identifiers

PMID: 23222642
DOI: 10.1038/nsmb.2456
PMCID: PMC3539207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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